What is The Sinclair Method? A Science-Backed Approach to Overcoming Alcohol Use Disorder

Key Takeaways

• The Sinclair Method (TSM) is a medication-assisted treatment for alcohol use disorder (AUD).

• It involves taking Naltrexone before drinking to gradually reduce alcohol cravings.

• Developed by Dr David Sinclair, TSM is backed by 35 years of research and 125 clinical trials.

• Unlike traditional abstinence-based treatments, TSM allows individuals to continue drinking while rewiring the brain’s relationship with alcohol.

• The goal is Pharmacological Extinction, meaning alcohol loses its addictive hold over time.

Understanding The Sinclair Method

The Sinclair Method (TSM) is a science-based approach to treating alcohol dependence. Unlike conventional recovery methods that demand immediate abstinence, TSM works by weakening alcohol’s reward in the brain using Naltrexone, a medication that blocks the pleasure response triggered by drinking.

With consistent use, TSM helps individuals drink less over time without cravings or withdrawal symptoms, leading to what’s known as Pharmacological Extinction—where alcohol addiction is effectively unlearned.

The Science Behind TSM

Dr David Sinclair dedicated 35 years of research to studying alcohol addiction and developed The Sinclair Method based on the principles of operant conditioning—the idea that behaviours reinforced by rewards can be modified or eliminated.

His research, backed by 125 clinical trials, showed that taking Naltrexone before drinking disrupts the brain’s reinforcement loop, weakening alcohol cravings.

Here’s how it works:

• Step 1: Taking Naltrexone – The individual takes one 50mg Naltrexone tablet at least one hour before drinking.

• Step 2: Blocking Endorphins – Naltrexone prevents alcohol from triggering the brain’s reward system, reducing the pleasurable effects.

• Step 3: Weakening Alcohol’s Grip – Over time, the brain stops associating alcohol with pleasure, leading to fewer cravings and less consumption.

• Step 4: Pharmacological Extinction – Eventually, alcohol dependence fades, making it easier to drink less or stop altogether.

How is The Sinclair Method Different?

Unlike traditional alcohol recovery approaches that focus on immediate sobriety, The Sinclair Method takes a gradual, science-backed approach to reducing alcohol dependence.

Benefits of TSM:

✅ No forced abstinence – You can continue drinking while gradually reducing dependence.
✅ Higher success rate – Research suggests TSM has a 78% success rate, significantly higher than willpower-based methods.
✅ No major withdrawal symptoms – Since alcohol consumption continues, there’s no sudden shock to the system.
✅ Long-term effectiveness – Once cravings are extinguished, the risk of relapse is much lower.

If you’re considering this approach, you can book a Free Screen Call to see if it is a fit for you?

The Role of Naltrexone in TSM

Naltrexone is an NICE-approved medication commonly used for alcohol and opioid dependence. In The Sinclair Method, it plays a critical role in:

• Blocking the pleasurable effects of alcohol

• Reducing cravings over time

• Lowering the risk of binge drinking

• Helping the brain “unlearn” addiction

For TSM to be effective, Naltrexone must be taken consistently before drinking. Skipping doses or stopping prematurely can lead to relapse, as the brain may re-establish alcohol cravings.

Evidence-Based Success

The Sinclair Method is one of the most researched alcohol treatment methods, with:

• 35 years of scientific study

• 125 clinical trials supporting its effectiveness

• A 78% success rate when followed correctly

A great way to understand the impact of TSM is through the documentary One Little Pill, which explores real-life success stories. To watch it, visit our One Little Pill page for your Free viewing.

Is The Sinclair Method Right for You?

The Sinclair Method could be a good option if you:

✔️ Have tried quitting before but relapsed
✔️ Want a scientific, medically backed treatment instead of relying on willpower
✔️ Prefer a non-abstinence-based approach
✔️ Are committed to taking Naltrexone before drinking consistently

If you’re curious about whether TSM is a good fit for you, we offer a Free Screening Call.

Final Thoughts

The Sinclair Method is a ground-breaking, evidence-based approach to overcoming alcohol dependence. With decades of research, over 100 clinical trials, and thousands of success stories, it offers a real, science-backed solution for those looking to regain control over their drinking.

If you're ready to explore TSM and how it could help you, visit our Rethink Drink website and take the first step towards a healthier relationship with alcohol.