The Sinclair Method (TSM) is a medically proven approach to reducing and overcoming alcohol dependence – one that flips conventional treatment on its head. Rather than asking you to quit drinking from day one, TSM invites you to do something far simpler: take a tablet of naltrexone one hour before drinking.
The Sinclair Method is a treatment for Alcohol Use Disorder (AUD) that involves taking the medication naltrexone one to two hours before drinking. Naltrexone blocks endorphins released by alcohol, reducing the brain’s reinforcement of drinking behaviour. Over time, this leads to a natural decrease in alcohol consumption—a process known as pharmacological extinction.
When facing alcohol dependency, many are told that immediate and total abstinence is the only way forward. This “cold turkey” approach, while well-intentioned, can be physically dangerous and psychologically harsh. But there’s another path — one backed by science and thousands of personal success stories: harm reduction through The Sinclair Method (TSM).
For those of us navigating the difficult landscape of alcohol recovery, finding a method that actually works can feel overwhelming. Many traditional approaches rely heavily on willpower and abstinence, often leading to feelings of guilt or failure when relapse occurs. But what if there was a method that used science to change the brain's relationship with alcohol—without requiring you to quit cold turkey?